Xenón Serrano-Martín, Gilberto Payares, Alexis Mendoza-León
Laboratorio de Bioquímica y Biología Molecular de Parásitos, Instituto de Biología Experimental, Facultad de Ciencias, Universidad Central de Venezuela, Apartado 47577, Caracas 1041A, Venezuela.
Antimicrobial agents and chemotherapy 2006 DecGlibenclamide reduced the rate of lesion growth in BALB/c mice infected with Leishmania (Leishmania) mexicana, the effect was dose dependent, and the highest dose proved more effective than glucantime. Cross-resistance to glucantime was found in animals infected with a glibenclamide-resistant line, but combined therapy reduced lesion progression even in the glibenclamide-resistant strain.
Xenón Serrano-Martín, Gilberto Payares, Alexis Mendoza-León. Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis. Antimicrobial agents and chemotherapy. 2006 Dec;50(12):4214-6
PMID: 17015627
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