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The diltiazem binding site of L-type calcium channels is the least characterized to date. In this paper, we present some of the available chemotypes that bind to the benzothiazepine binding site: natural compounds, compounds synthesized by varying the benzothiazepine scaffold, and compounds discovered by means of computational approaches.

Citation

R Budriesi, P Ioan, E Carosati, G Cruciani, B S Zhorov, A Chiarini. Ligands of diltiazem binding site: an overview of some chemotypes. Mini reviews in medicinal chemistry. 2009 Oct;9(12):1379-88

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PMID: 19929811

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