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The enzyme xanthine dehydrogenase (XDH) from the purple photosynthetic bacterium Rhodobacter capsulatus catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid as part of purine metabolism. The native electron acceptor is NAD(+) but herein we show that uric acid in its 2-electron oxidized form is able to act as an artificial electron acceptor from XDH in an electrochemically driven catalytic system. Hypoxanthine oxidation is also observed with the novel production of uric acid in a series of two consecutive 2-electron oxidation reactions via xanthine. XDH exhibits native activity in terms of its pH optimum and inhibition by allopurinol. © 2011 American Chemical Society

Citation

Palraj Kalimuthu, Silke Leimkühler, Paul V Bernhardt. Xanthine dehydrogenase electrocatalysis: autocatalysis and novel activity. The journal of physical chemistry. B. 2011 Mar 24;115(11):2655-62

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PMID: 21361328

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