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In the Formalin-induced pulpitis of rats and the electrically stimulated pulps of dogs, a bradykininlike substance developed by the pulps and released into a saline pool on the exposed pulps disappeared after a local application of Apernyl solution. This suggests that the possible pain-reducing or anti-in-flammatory effect of Apernyl is a result of its inhibiting bradykinin production.


T Kudo, M Kawagoe, T Hayashi, J Takezawa, R Inoki. Inhibitory effect of Apernyl on production of bradykininlike substance in pulp. Journal of dental research. 1975 Sep-Oct;54(5):1082-6

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PMID: 1081101

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