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We have devised a general synthesis of Mg(2+) indicators which is based on the aminophenol triacetic acid (APTRA) structure. The key step is a palladium-catalyzed coupling reaction of a precursor of the APTRA ligand with a fluorescent group. This strategy resulted in new ratioable fluorescent APTRA indicators and the finding that the fluorescence response of these indicators is different for Mg(2+) and Ca(2+) in some cases. We believe that this represents a generally useful approach for combining fluorophore and chelator functionalities.

Citation

P A Otten, R E London, L A Levy. A new approach to the synthesis of APTRA indicators. Bioconjugate chemistry. 2001 Jan-Feb;12(1):76-83

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PMID: 11170369

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