Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Researches indicated that Tripterygium wilfordii possess antitumor activity. The current study was designed to investigate inhibitive effect of several monomes of Tripterygium wilfordii on the proliferation of glioma cells. The effect of three monomes from Tripterygium wilfordii on the proliferation of glioma cell lines SHG44, C6, and U251 in vitro was examined by using MTT assay. Immunohistochemistry was used to examine the expression of Bax, Bcl-2 after treatment of triptolide and celastrol. The proliferation of glioma cells was remarkably inhibited by triptolide and celastrol. They both increased expression of Bax and decreased expression of Bcl-2 in the SHG44 cells. Triptolide and celastrol inhibit the proliferation of glioma cells in vitro, which was associated with promoting the expression of Bax and inhibiting the expression of Bcl-2 and accelerating cell apotosis.

Citation

You-xin Zhou, Yu-lun Huang, Qi-nian Xu, Ming Ye, Cheng-fa Sun, Dai Zhou. Several monomes from Tripterygium wilfordii inhibit proliferation of glioma cells in vitro]. Ai zheng = Aizheng = Chinese journal of cancer. 2002 Oct;21(10):1106-8

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 12508653

View Full Text