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The chemical investigation of the methanolic extract of the root bark of Waltheria douradinha (Sterculiaceae) afforded an unusual quinolinone alkaloid named waltherione-A (1). Its structure was determined mainly by NMR spectroscopic methods. The antibacterial activity of waltherione-A (1) and the corresponding O-methylated derivative (2) was tested against three gram-negative and three gram-positive bacteria, with only (2) having moderate activity.

Citation

Solange C S M Hoelzel, Eleno R Vieira, Sandro R Giacomelli, Ionara I Dalcol, Nilo Zanatta, Ademir F Morel. An unusual quinolinone alkaloid from Waltheria douradinha. Phytochemistry. 2005 May;66(10):1163-7

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PMID: 15924921

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