Pharmacokinetics of pueraria flavonoids from Pueraria lobata by anti-oxidant pharmacodynamics effect method].

Xiao-bin Jia, Yin Cai, Yan Chen, Xu-dong Cheng, Chen-yi Fan, Ya-fang Shi

Jiangsu Academy of Chinese Medicine Sciences, Jiangsu Engineering and Technology Research Center for Modern Chinese Pharmaceutical Preparation, Nanjing 210028, China.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2007 Nov

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To study the pharmacokinetics of pueraria flavonoids(PF) from Pueraria lobata. An anti-oxidant pharmacodynamics effect method was quoted to detect the antioxidant ability of PF contained in rats plasm after oral delivered, measures the fluorescence intensity, and calculates the concentration of components in plasma, then we can get the plot of the change of the content of PF contained in rats plasm, and then we can get the pharmacokinetics of Pueraria Flavonoids pellets. The AUC of Pueraria lobata isoflavone pellets is 4.40-fold of Yufengningxin tablets. It can enhance the bioavailability of PF by made it to pellets.

Citation

Xiao-bin Jia, Yin Cai, Yan Chen, Xu-dong Cheng, Chen-yi Fan, Ya-fang Shi. Pharmacokinetics of pueraria flavonoids from Pueraria lobata by anti-oxidant pharmacodynamics effect method]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Nov;32(22):2370-3