Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia. natglu@hotmail.com.
Biochemistry. Biokhimii͡a 2008 JulCadherin-mediated cell-cell adhesion defines the integrity of most tissues. Cell-cell adherens junctions are dynamic structures whose functional state is regulated by interactions of cadherin with beta-catenin, p120, and actin cytoskeleton structures. Small GTPases of the Rho family and GTPase Rap1 play the central role in the formation and maintenance of cell-cell adhesion. Aberrant activation of signaling pathways, transcriptional repression of the E-cadherin gene, ectopic expression of N-cadherin, and disturbances in regulation of adhesive and transcriptional functions of beta-catenin stimulate tumor progression.
N A Gloushankova. Changes in regulation of cell-cell adhesion during tumor transformation. Biochemistry. Biokhimii͡a. 2008 Jul;73(7):742-50
PMID: 18707582
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