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Nalidixic acid (NA) and its main metabolite, 7-hydroxymethylnalidixic acid (OH-NA), are simultaneously determined by applying artificial neural networks (ANNs), to their square wave voltammetric signals. The scores of a PCR model, built with the voltammetric data of a set of standard samples, recorded between -0.70 and -1.0V, are used as training set for the net for each compound. The trained nets (ANNs) are used for the simultaneous determination of NA and OH-NA in urine. The recovery values are comprised between 91 and 109% for NA and between 82 and 112% for OH-NA, being these results better than the results obtained by application of partial least squares (PLS) multivariate calibration.

Citation

Agustina Guiberteau, Teresa Galeano Díaz, María I Rodríguez Cáceres, Juan M Ortiz Burguillos, Isabel Durán Merás, Francisco Salinas López. Polarography and artificial neural network for the simultaneous determination of nalidixic acid and its main metabolite (7-hydroxymethylnalidixic acid). Talanta. 2004 Feb 6;62(2):357-65


PMID: 18969303

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