Mobin A Tawakkul, Rakhi B Shah, Ahmed Zidan, Vilayat A Sayeed, Mansoor A Khan
Division of Product Quality Research/Office of Testing and Research, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Sciences, Silver Spring, Maryland 20993-002, USA.
Pharmaceutical development and technology 2009The purpose of the study was to investigate the complexation between a weakly basic drug (risperidone) and an ion exchange resin (amberlite IRP-64) used as a taste-masking agent via two preparation methods: physical mixture and solvent evaporation. Both methods were prepared in different drug-to-resin ratios by weight (1:1, 1:2, 1:4, 1:6). Physicochemical characterizations were performed using differential scanning calorimetry, x-ray diffraction, infra-red spectroscopy, Raman spectroscopy, near infra-red spectroscopy, chemical imaging and drug release studies. These physicochemical techniques revealed that risperidone formed complex with the resin via the solvent evaporation method where enhanced dissolution occurred but not with the physical mixtures.
Mobin A Tawakkul, Rakhi B Shah, Ahmed Zidan, Vilayat A Sayeed, Mansoor A Khan. Complexation of risperidone with a taste-masking resin: novel application of near infra-red and chemical imaging to evaluate complexes. Pharmaceutical development and technology. 2009;14(4):409-21
PMID: 19630698
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