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Four hapalindole-related alkaloids, namely fischambiguines A and B, ambiguine P, ambiguine Q nitrile as well as ambiguine G nitrile were identified from the cultured cyanobacterium Fischerella ambigua (UTEX 1903). The structures were determined by spectroscopic analysis including MS, 1D and 2D NMR and X-ray crystallography. The alkaloids possessed fused pentacyclic and hexacyclic carbon skeletons. Fischambiguine B displayed a strong inhibitory activity against Mycobacterium tuberculosis with an MIC value of 2 μM, with no detectable cytotoxicity in a Vero cell line. Copyright © 2010 Elsevier Ltd. All rights reserved.

Citation

Shunyan Mo, Aleksej Krunic, Bernard D Santarsiero, Scott G Franzblau, Jimmy Orjala. Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua. Phytochemistry. 2010 Dec;71(17-18):2116-23

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PMID: 20965528

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