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We developed abscinazole-E1 (Abz-E1), a specific inhibitor of abscisic acid (ABA) 8'-hydroxylase (CYP707A). This inhibitor was designed and synthesized as an enlarged analogue of uniconazole (UNI), a well-known plant growth retardant, which inhibits a gibberellin biosynthetic enzyme (ent-kaurene oxidase, CYP701A) as well as CYP707A. Our results showed that Abz-E1 functions as a potent inhibitor of CYP707A and a poor inhibitor of CYP701A both in vitro and in vivo. Abz-E1 application to plants resulted in improved desiccation tolerance and an increase in endogenous ABA. Copyright © 2010 Elsevier Ltd. All rights reserved.

Citation

Mariko Okazaki, Hataitip Nimitkeatkai, Taku Muramatsu, Hikaru Aoyama, Kotomi Ueno, Masaharu Mizutani, Nobuhiro Hirai, Satoru Kondo, Toshiyuki Ohnishi, Yasushi Todoroki. Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8'-hydroxylase CYP707A. Bioorganic & medicinal chemistry. 2011 Jan 1;19(1):406-13

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PMID: 21115253

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