Jin Young Choi, Jun Yu, Dong Beom Yang, Kongtae Ra, Kyung Tae Kim, Gi Hoon Hong, Kyung Hoon Shin
Marine Environment and Pollution Prevention Research Department, Korea Ocean Research and Development Institute, Ansan 426-744, Republic of Korea.
Marine environmental research 2011 AprThe acetylthiocholine (ATC) - cleaving cholinesterase (ChE) activity in Manila clam, which is widely distributed throughout the coastal environment of Korea, was assayed as a potentially useful biomarker of organophosphorous pesticides (OPs). A clear dose-response relationship was determined between inhibited ChE in adductor muscle of clams and four OPs (methidathion, chlorpyrifos, diazinon, IBP) which are heavily used OPs in Korea. The measured EC(50)-24 h values of methidathion, chlorpyrifos, diazinon, and IBP for Ruditapes philippinarum were 7.16 μg l(-1), 0.34 mg l(-1), 3.01 mg l(-1), and 3.41 mg l(-1), respectively. In field studies, ChE activity in Manila clams collected from 23 stations in the mid-western coastal region demonstrated spatial variation with statistical differences. These results suggest that ChE activity in R. philippinarum is a potential biomarker for assessing organophosphorous pesticide contamination in coastal environments. Copyright © 2011 Elsevier Ltd. All rights reserved.
Jin Young Choi, Jun Yu, Dong Beom Yang, Kongtae Ra, Kyung Tae Kim, Gi Hoon Hong, Kyung Hoon Shin. Acetylthiocholine (ATC)--cleaving cholinesterase (ChE) activity as a potential biomarker of pesticide exposure in the Manila clam, Ruditapes philippinarum, of Korea. Marine environmental research. 2011 Apr;71(3):162-8
PMID: 21262527
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