Evaluation of uridine 5'-eicosylphosphate as a stimulant of cyclic AMP-dependent cellular function.

Masahiro Yutani, Akira Ogita, Ken-Ichi Fujita, Yoshinosuke Usuki, Toshio Tanaka

Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.

General physiology and biophysics 2011 Mar

filter terms:

Sporulation of the yeast Saccharomyces cerevisiae is negatively regulated by cyclic AMP (cAMP). This microbial cell differentiation process was applied for the screening of a substance that can elevate the intracellular cAMP level. Among nucleoside 5'-alkylphosphates, uridine 5'-eicosylphosphate (UMPC20) selectively and predominantly inhibited ascospore formation of the yeast cells. We suppose the inhibitory effect of UMPC20 could indeed reflect the elevation of the cellular cAMP level.

Citation

Masahiro Yutani, Akira Ogita, Ken-Ichi Fujita, Yoshinosuke Usuki, Toshio Tanaka. Evaluation of uridine 5'-eicosylphosphate as a stimulant of cyclic AMP-dependent cellular function. General physiology and biophysics. 2011 Mar;30(1):106-9