Li-Hua Hang, Dong-Hua Shao, Yue-Ping Gu, Ti-Jun Dai
Department of Anesthesiology, the Affiliated People's Hospital of Jiangsu University and the First People's Hospital of Zhenjiang, Zhenjiang, Jiangsu, 212002, PR China. hanglihua@yahoo.com.cn
Pharmacological reports : PR 2011In the present study, the role of kainate (KA) receptors in hypnosis and analgesia induced by emulsified inhalation anesthetics was investigated. A mouse model of hypnosis and analgesia was established by an intraperitoneal injection of emulsified enflurane, isoflurane or sevoflurane. We intracerebroventricularly (icv) or intrathecally (it) administered KA, a KA receptor agonist to mice. The effects of the KA on the sleep time were observed using a hypnosis test, and the tail-withdrawal latency was analyzed using the tail-withdrawal test. In the hypnosis test, KA (2.5, 5 or 10 ng; icv administered) treatment had no distinctive effects on the sleep time of mice treated with emulsified inhalation anesthetics. In the tail-withdrawal test, KA (0.2, 0.4 or 0.8 ng; it administered) treatment significantly and dose-dependently decreased the tail-withdrawal latency of mice treated with emulsified anesthetics. These results suggested that KA receptors may modulate the analgesic but not hypnotic effects induced by emulsified enflurane, isoflurane or sevoflurane.
Li-Hua Hang, Dong-Hua Shao, Yue-Ping Gu, Ti-Jun Dai. Involvement of kainate receptors in the analgesic but not hypnotic effects induced by inhalation anesthetics. Pharmacological reports : PR. 2011;63(4):949-55
PMID: 22001982
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