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Since the subtypes of α(1)-adrenergic receptor have been thoroughly determined, to date medicinal chemists raise their deliberation on how to conceive selective α(1)-adrenergic receptor antagonist with the minimal side effects. It needs to be well recognized that natural products can exist as a significant source of drug leads, thus portraying a consequential capacity in drug design and development. The current review article would like to present a comprehensive survey on natural products, mainly including alkaloids and flavonoids, which exhibit α(1)-adrenergic receptor antagonistic activities.

Citation

W Li, L Du, M Li. Alkaloids and flavonoids as α(1)-adrenergic receptor antagonists. Current medicinal chemistry. 2011;18(32):4923-32

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PMID: 22050743

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