Kamal Nain Singh, Paramjit Singh, Pushpinder Singh, Nand Lal, Sandeep Kumar Sharma
Department of Chemistry, Punjab University, Chandigarh 160014, India. kns@pu.ac.in
Bioorganic & medicinal chemistry letters 2012 Jul 1An efficient asymmetric Michael addition of cyclic ketones to β-nitrostyrenes using secondary diamine as an organocatalyst derived from l-proline and (R)-α-methylbenzyl amine has been described. This pyrrolidine based catalyst 1 was found to be very effective to synthesize various γ-nitrocarbonyl compounds in good yield (up to 81%) with excellent stereoselectivity (up to >99:1 dr and >99% ee). Copyright © 2012 Elsevier Ltd. All rights reserved.
Kamal Nain Singh, Paramjit Singh, Pushpinder Singh, Nand Lal, Sandeep Kumar Sharma. Pyrrolidine based chiral organocatalyst for efficient asymmetric Michael addition of cyclic ketones to β-nitrostyrenes. Bioorganic & medicinal chemistry letters. 2012 Jul 1;22(13):4225-8
PMID: 22672804
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