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It is currently said that CO has anti-inflammatory and antiapoptosis effects and it has attracted attention as a medical gas. We used CO for rat hearts and conducted a preservation experiment. We isolated rat hearts, placed them into a specially made chamber, filled the chamber with a gas mixture of PCO (4,000 hPa) and PO(2) (3,000 hPa), and preserved the hearts in a refrigerator at 4°C for 48 h. We then performed a heterotrophic transplantation on the neck of each recipient rat and resuscitated the preserved hearts. We herein report our findings.

Citation

Naoyuki Hatayama, Munekazu Naito, Shuichi Hirai, Yu Yoshida, Tomohiro Kojima, Kunihiro Seki, Xiao-Kang Li, Masahiro Itoh. Preservation by desiccation of isolated rat hearts for 48 hours using carbon monoxide (PCO = 4,000 hPa) and oxygen (PO(2) = 3,000 hPa). Cell transplantation. 2012;21(2-3):609-15

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PMID: 22793070

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