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It was found that 3-fold intranasal administration of Arg-Pro-Gly-Pro peptide in a dose of 1 mg/kg body weight under conditions of experimental persistent hyperglycemia prevents the development of diabetes in experimental rats and produces normoglycemic, anticoagulant, fibrinolytic, and antiplatelet effects.

Citation

T A Shubina, N F Myasoedov, L A Andreeva, L A Lyapina, A M Ulyanov, T J Obergan, V E Pastorova. Anticoagulant, fibrinolytic, and hypoglycemic effects of tetrapeptide Arg-Pro-Gly-Pro. Bulletin of experimental biology and medicine. 2012 Jul;153(3):327-30

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PMID: 22866303

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