Artificial cytoskeletal structures within enzymatically active bio-inorganic protocells.

Ravinash Krishna Kumar, Mei Li, Sam N Olof, Avinash J Patil, Stephen Mann

Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, UK.

Small (Weinheim an der Bergstrasse, Germany) 2013 Feb 11

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The fabrication of enzymatically active, semi-permeable bio-inorganic protocells capable of self-assembling a cytoskeletal-like interior and undergoing small-molecule dephosphorylation reactions is described. Reversible disassembly of an amino acid-derived supramolecular hydrogel within the internalized reaction space is used to tune the enzymatic activity of the nanoparticle-bounded inorganic compartments. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Ravinash Krishna Kumar, Mei Li, Sam N Olof, Avinash J Patil, Stephen Mann. Artificial cytoskeletal structures within enzymatically active bio-inorganic protocells. Small (Weinheim an der Bergstrasse, Germany). 2013 Feb 11;9(3):357-62