Comparison of cell-mediated immunity induced by three commercial single-dose Mycoplasma hyopneumoniae bacterins in pigs.

Hwi Won Seo, Kiwon Han, Yeonsu Oh, Changhoon Park, Eun Jeong Choo, Sung-Hoon Kim, Bog-Hieu Lee, Chanhee Chae

Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.

The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2013 Feb

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This study was to compare the degree of cell-mediated immunity induced by three commercial Mycoplasma hyopneumoniae bacterins using interferon-γ (IFN-γ) measurements, lymphocyte stimulation assays and delayed-type hypersensitivity tests. Serum IFN-γ levels were significantly elevated in all four vaccinated pig groups at 21 days post-vaccination (P<0.05). Lymphocytes isolated 21 days post-vaccination exhibited significantly more proliferation in response to M. hyopneumoniae than lymphocytes isolated 0 day pre-vaccination (P<0.05). Following intradermal injection of M. hyopneumoniae antigen at 14, 21 or 28 days post-vaccination, all pigs in the four vaccinated groups displayed skin reactions characterized by circumscribed, often erythematous nodules. Taken together, these demonstrate that all three commercial single-dose M. hyopneumoniae bacterins used in this study induce varying degrees of cell-mediated immunity.

Citation

Hwi Won Seo, Kiwon Han, Yeonsu Oh, Changhoon Park, Eun Jeong Choo, Sung-Hoon Kim, Bog-Hieu Lee, Chanhee Chae. Comparison of cell-mediated immunity induced by three commercial single-dose Mycoplasma hyopneumoniae bacterins in pigs. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 2013 Feb;75(2):245-7