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Chemical studies on Hamelia patens (Rubiaceae) micropropagated plantlets allowed production of a new monoterpenoid oxindole alkaloid, named (-)-hameline (7), together with eight known alkaloids, tetrahydroalstonine (1), aricine (2), pteropodine (3), isopteropodine (4), uncarine F (5), speciophylline (6), palmirine (8), and rumberine (9). The structure of the new alkaloid was assigned on the basis of 1D and 2D NMR spectroscopy, mass spectrometry, and molecular modeling.

Citation

David Paniagua-Vega, Carlos M Cerda-García-Rojas, Teresa Ponce-Noyola, Ana C Ramos-Valdivia. A new monoterpenoid oxindole alkaloid from Hamelia patens micropropagated plantlets. Natural product communications. 2012 Nov;7(11):1441-4

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PMID: 23285803

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