Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

A finely tuned balance of translation, storage and decay of mRNAs (mRNAs) is important for the regulation of gene expression. In eukaryotic cells, this takes place in dynamic cytoplasmic RNA-protein granules termed Processing bodies (P-bodies). In this study, by using immunoelectron tomography, 3D modeling and template matching, we analyze the size and the organization of the polysomes in the vicinity of human P-bodies. Our results show the presence of several polysomes that are compatible with a translational activity around P-bodies. Therefore, movement of mRNAs between polysomes and P-bodies can take place when the two compartments are in close contact. The presence of initiation factors in the proximity of P-bodies also suggests that translation of mRNAs can resume at the periphery of these granules.

Citation

Nicolas Cougot, Anne-Elisabeth Molza, Emmanuel Giudice, Annie Cavalier, Daniel Thomas, Reynald Gillet. Structural organization of the polysomes adjacent to mammalian processing bodies (P-bodies). RNA biology. 2013 Feb;10(2):314-20

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 23324601

View Full Text