Section of Maternal Fetal Medicine, Bridgeport Hospital-Yale New Haven Health, Bridgeport, USA.
Connecticut medicine 2013 JanMarkedly elevated maternal serum alpha-fetoprotein (MSAFP) levels were found in a 26 year old healthy, nulliparous Polish woman during pregnancy. No fetal abnormalities were identified on targeted ultrasound and amniocentesis revealed normal amniotic fluid alpha-fetoprotein (AFP) values. Maternal ultrasound screening for liver and ovarian germ cell malignancies were also negative. The mother delivered a live, healthy female at term and a repeat maternal serum AFP postpartum remained markedly elevated, suggestive of hereditary persistence of alpha-fetoprotein.
Kara Rood, Robert Stiller. Hereditary persistence of alpha-fetoprotein: a rare cause for unexplained alpha-fetoprotein elevations in pregnancy. Connecticut medicine. 2013 Jan;77(1):43-5
PMID: 23427373
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