Carolyn L Ladd, Daniela Sustac Roman, André B Charette
Centre in Green Chemistry and Catalysis, Department of Chemistry, Université de Montréal, P.O. Box 6128 Station Downtown, Montréal, Québec, H3C 3J7, Canada.
Organic letters 2013 Mar 15The Pd-catalyzed, Ag(I)-mediated intramolecular direct arylation of cyclopropane C-H bonds is described. Various spiro 3,3'-cyclopropyl oxindoles can be obtained in good to excellent yields from easily accessible 2-bromoanilides. The kinetic isotope effect was determined and epimerization studies were conducted, suggesting that the formation of a putative Pd-enolate is not operative and that the reaction proceeds via a C-H arylation pathway.
Carolyn L Ladd, Daniela Sustac Roman, André B Charette. Silver-promoted, palladium-catalyzed direct arylation of cyclopropanes: facile access to spiro 3,3'-cyclopropyl oxindoles. Organic letters. 2013 Mar 15;15(6):1350-3
PMID: 23452033
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