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Centromeres play essential roles in equal chromosome segregation by directing the assembly of the microtubule binding kinetochore and serving as the cohesion site between sister chromatids. Here, we review the significant recent progress in our understanding of centromere protein assembly and how centromere proteins form the foundation of the kinetochore. Copyright © 2013 Elsevier Ltd. All rights reserved.

Citation

Frederick G Westhorpe, Aaron F Straight. Functions of the centromere and kinetochore in chromosome segregation. Current opinion in cell biology. 2013 Jun;25(3):334-40

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PMID: 23490282

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