María Guzmán-Fulgencio, José L Jiménez, María A Jiménez-Sousa, José M Bellón, Mónica García-Álvarez, Vicente Soriano, Paloma Gijón-Vidaurreta, Enrique Bernal-Morell, Pompeyo Viciana, M Ángeles Muñoz-Fernández, Salvador Resino
Journal of acquired immune deficiency syndromes (1999) 2014 Jan 1Our aim was to explore the association among ACSM4 and PECI polymorphisms and AIDS progression in 454 HIV-infected patients never treated with antiretroviral drugs (146 long-term nonprogressors, 228 moderate progressors, and 80 rapid progressors). For ACSM4 polymorphisms, rs7137120 AA/AG and rs7961991 CC/CT genotypes had higher odds of having a rapid AIDS progression [odds ratio (OR) = 3.21; 95% of confidence interval (95% CI) = 1.26 to 8.16; P = 0.014 and OR = 3.60; 95% CI = 1.38 to 9.36; P = 0.009, respectively]. Additionally, the ACSM4 haplotype integrated for both rs7961991 A and rs7137120 C alleles had higher odds of having a rapid AIDS progression (OR = 2.85; 95% CI = 1.28 to 6.25; P = 0.010). For PECI polymorphisms, no significant associations were found. In conclusion, ACSM4 polymorphisms might play a significant role in AIDS progression.
María Guzmán-Fulgencio, José L Jiménez, María A Jiménez-Sousa, José M Bellón, Mónica García-Álvarez, Vicente Soriano, Paloma Gijón-Vidaurreta, Enrique Bernal-Morell, Pompeyo Viciana, M Ángeles Muñoz-Fernández, Salvador Resino. ACSM4 polymorphisms are associated with rapid AIDS progression in HIV-infected patients. Journal of acquired immune deficiency syndromes (1999). 2014 Jan 1;65(1):27-32
PMID: 23982661
View Full Text