Correlation Engine 2.0
Clear Search sequence regions


  • ACSM4 (6)
  • adult (1)
  • alleles (1)
  • case control studies (1)
  • CD4 (1)
  • female (1)
  • genotypes (1)
  • had (2)
  • hiv (3)
  • hiv long- term survivors (1)
  • humans (1)
  • long term survivors (1)
  • lymphocyte (1)
  • male (1)
  • odds ratio (3)
  • over (1)
  • patients (2)
  • PECI (2)
  • protein human (1)
  • rapid (4)
  • rs7137120 (2)
  • rs7961991 (2)
  • young adult (1)
  • Sizes of these terms reflect their relevance to your search.

    Our aim was to explore the association among ACSM4 and PECI polymorphisms and AIDS progression in 454 HIV-infected patients never treated with antiretroviral drugs (146 long-term nonprogressors, 228 moderate progressors, and 80 rapid progressors). For ACSM4 polymorphisms, rs7137120 AA/AG and rs7961991 CC/CT genotypes had higher odds of having a rapid AIDS progression [odds ratio (OR) = 3.21; 95% of confidence interval (95% CI) = 1.26 to 8.16; P = 0.014 and OR = 3.60; 95% CI = 1.38 to 9.36; P = 0.009, respectively]. Additionally, the ACSM4 haplotype integrated for both rs7961991 A and rs7137120 C alleles had higher odds of having a rapid AIDS progression (OR = 2.85; 95% CI = 1.28 to 6.25; P = 0.010). For PECI polymorphisms, no significant associations were found. In conclusion, ACSM4 polymorphisms might play a significant role in AIDS progression.

    Citation

    María Guzmán-Fulgencio, José L Jiménez, María A Jiménez-Sousa, José M Bellón, Mónica García-Álvarez, Vicente Soriano, Paloma Gijón-Vidaurreta, Enrique Bernal-Morell, Pompeyo Viciana, M Ángeles Muñoz-Fernández, Salvador Resino. ACSM4 polymorphisms are associated with rapid AIDS progression in HIV-infected patients. Journal of acquired immune deficiency syndromes (1999). 2014 Jan 1;65(1):27-32

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 23982661

    View Full Text