The chemical synthesis of staphyloferrin A, a siderophore used by Staphylococcus bacteria for ferric iron retrieval, has been achieved with 79% yield via solid phase peptide synthesis (SPPS). Biological activity of synthetic staphyloferrin A has been confirmed by demonstrating its capture and uptake by live S. aureus.
Rajesh K Pandey, Gregory G Jarvis, Philip S Low. Chemical synthesis of staphyloferrin A and its application for Staphylococcus aureus detection. Organic & biomolecular chemistry. 2014 Mar 21;12(11):1707-10
PMID: 24500249
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