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Parasitological diagnostic methods for schistosomiasis lack sensitivity, especially in regions of low endemicity. The objective of this study was to determine the prevalence of Schistosoma mansoni infections by antibody detection using the indirect immunofluorescence assay (IFA-IgM) and circumoval precipitin test (COPT). Serum samples of 572 individuals were randomly selected. The IFA-IgM and COPT were used to detect anti-S. mansoni antibodies. Of the patients studied, 15.9% (N = 91) were IFA-IgM positive and 5.1% (N = 29) had COPT reactions (P < 0.001 by McNemar's test). Immunodiagnostic techniques showed higher infection prevalence than had been previously estimated. This study suggests that combined use of these diagnostic tools could be useful for the diagnosis of schistosomiasis in epidemiological studies in areas of low endemicity. © The American Society of Tropical Medicine and Hygiene.

Citation

Maria Cristina Carvalho do Espírito-Santo, Pedro Luiz Pinto, Cybele Gargioni, Monica Viviana Alvarado-Mora, Vera Lúcia Pagliusi Castilho, João Ranato Rebello Pinho, Expedito José de Albuquerque Luna, Ronaldo Cesar Borges Gryschek. Detection of Schistosoma mansoni antibodies in a low-endemicity area using indirect immunofluorescence and circumoval precipitin test. The American journal of tropical medicine and hygiene. 2014 Jun;90(6):1146-52

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PMID: 24639303

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