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    To study the chemical constituents from the roots of Buleurum bicaule Helm (Apiaceae). Silica gel, Sephadex LH-20, MPLC Rp-C18 column chromatography, and HPLC were used for isolation of compounds. The structures were elucidated on the basis of 1D- and 2D-NMR technology and HRESI-MS. Compounds were evaluated in vitro for their inhibitory ability against the proliferation of rat mesangial cells by the MTT method. Twelve compounds were isolated, and their structures were identified on the basis of their spectroscopic and physico-chemical properties as 13, 28-epoxy-olean-11-en-3-one (1), saikogenin E (2), saikogenin G (3), 11α-methoxy-3β, 16β, 23, 28-tetrahydroxyolean-12-ene (4), saikogenin D (5), prosaikogenin F (6), prosaikogenin A (7), prosaikogenin G (8), prosaikogenin D (9), laccaic acid (10b), methyl gallate (11), and ethyl gallate (12). Compounds 1, 2, 7, 8, and 10 were observed to have inhibitory activity against mesangial cell proliferationin to different degrees. Compound 1, 8, and 10 exhibit significant inhibitory effects on rat mesangial cell proliferation induced by Ang II. Copyright © 2014 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

    Citation

    Nan Xu, Ya-Nan Shi, Xu Zhong, Yue Cao, Li Wang, Tian-Zhu Jia. A new saikogenin from the roots of Bupleurum bicaule. Chinese journal of natural medicines. 2014 Apr;12(4):305-8

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    PMID: 24863358

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