The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas.

Vanni Caruso, Maria G Hägglund, Luca Badiali, Sonchita Bagchi, Sahar Roshanbin, Tauseef Ahmad, Helgi B Schiöth, Robert Fredriksson

Gene 2014 Dec 10

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The Rhodopsin family is a class of integral membrane proteins belonging to G protein-coupled receptors (GPCRs). To date, several orphan GPCRs are still uncharacterized and in this study we present an anatomical characterization of the GPR162 protein and an attempt to describe its functional role. Our results show that GPR162 is widely expressed in GABAergic as well as other neurons within the mouse hippocampus, whereas extensive expression is observed in areas related to energy homeostasis and hedonic feeding such as hypothalamus, amygdala and ventral tegmental area, regions known to be involved in the regulation of palatable food consumption. Copyright © 2014 Elsevier B.V. All rights reserved.

Citation

Vanni Caruso, Maria G Hägglund, Luca Badiali, Sonchita Bagchi, Sahar Roshanbin, Tauseef Ahmad, Helgi B Schiöth, Robert Fredriksson. The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas. Gene. 2014 Dec 10;553(1):1-6