Correlation Engine 2.0
Clear Search sequence regions


  • base sequence (1)
  • dna (2)
  • gene (1)
  • humans (2)
  • mice (2)
  • nucleic acid (1)
  • plants (1)
  • rats (2)
  • regions (3)
  • rna (3)
  • rna precursors (2)
  • rrna transcript (4)
  • yeast (2)
  • Sizes of these terms reflect their relevance to your search.

    rRNA is one of the few universal features of life, making it uniquely suited to assess phylogenetic relationships. The processing of the initial polycistronic rRNA transcript is also a conserved process, involving numerous cleavage events and the generation of secondary structures. The secondary structure of the internal transcribed spacer (ITS) regions of nuclear rRNA transcripts are well known for a wide variety of eukaryotes and have been used to aid in the alignment of these sequences for phylogenetic comparisons. By contrast, study of the processing of the initial rRNA transcripts has been largely limited to yeast, mice, rats, and humans. Here I examine the known cleavage sites in the two ITS regions and their positions relative to the secondary structure. A better understanding of the conservation of secondary structures and cleavage sites within the ITS regions will improve evolutionary inferences based on these sequences. Copyright © 2015 Elsevier Ltd. All rights reserved.

    Citation

    Annette W Coleman. Nuclear rRNA transcript processing versus internal transcribed spacer secondary structure. Trends in genetics : TIG. 2015 Mar;31(3):157-63

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 25648500

    View Full Text