Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity. Copyright © 2015. Published by Elsevier Ltd.
Christoforos Thomas, Jan-Åke Gustafsson. Progesterone receptor-estrogen receptor crosstalk: a novel insight. Trends in endocrinology and metabolism: TEM. 2015 Sep;26(9):453-4
PMID: 26277479
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