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    Systemic candidiasis is a leading cause of nosocomial bloodstream infection with a high mortality rate despite treatment. Immune-based strategies are needed to improve outcomes. We previously reported that genetic deficiency in the chemokine receptor CCR1 improves survival and ameliorates tissue damage in Candida-infected mice. Here, we found that treatment of immunocompetent Candida-infected mice with the CCR1-selective antagonist BL5923 improves survival, decreases the kidney fungal burden, and protects from renal tissue injury. Copyright © 2017 American Society for Microbiology.

    Citation

    Michail S Lionakis, Nathaniel D Albert, Muthulekha Swamydas, Chyi-Chia R Lee, Pius Loetscher, Dimitrios P Kontoyiannis. Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin. Antimicrobial agents and chemotherapy. 2017 Mar;61(3)

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    PMID: 27993850

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