Michal Tichý, Sabina Smoleń, Eva Tloušt'ová, Radek Pohl, Tomáš Oždian, Klára Hejtmánková, Barbora Lišková, Soňa Gurská, Petr Džubák, Marián Hajdúch, Michal Hocek
Journal of medicinal chemistry 2017 Mar 23Two isomeric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-substituted thieno[2',3':4,5]pyrrolo[2,3-d]pyrimidines and thieno[3',2':4,5]pyrrolo[2,3-d]pyrimidines) were synthesized by a sequence involving Negishi coupling of 4,6-dichloropyrimidine with iodothiophenes, nucleophilic azidation, and cyclization of tetrazolopyrimidines, followed by glycosylation and cross-couplings or nucleophilic substitutions at position 4. Most nucleosides (from both isomeric series) exerted low micromolar or submicromolar in vitro cytostatic activities against a broad panel of cancer and leukemia cell lines and some antiviral activity against HCV. The most active were the 6-methoxy, 6-methylsulfanyl, and 6-methyl derivatives, which were highly active to cancer cells and less toxic or nontoxic to fibroblasts.
Michal Tichý, Sabina Smoleń, Eva Tloušt'ová, Radek Pohl, Tomáš Oždian, Klára Hejtmánková, Barbora Lišková, Soňa Gurská, Petr Džubák, Marián Hajdúch, Michal Hocek. Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides. Journal of medicinal chemistry. 2017 Mar 23;60(6):2411-2424
PMID: 28221790
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