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    Redox stress related loss of beta cell function is a feature of diabetes. Exposure of beta cells and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell dysfunction. Direct molecular manipulation of NADPH oxidase-1 (NOX-1) has identified a key role for NOX-1 in cytokine-induced beta cell dysfunction. Plasmid driven elevation of NOX-1 resulted in elevated ROS, loss of glucose-stimulated-insulin-secretion and increased apoptosis. These outcomes on beta cell function are analogous to cytokine treatment. In contrast, reduction of NOX-1 expression, by shRNA, conferred protection to beta cells and islets from the damaging effects of inflammatory cytokines. Collectively, these data support the therapeutic potential for NOX-1 inhibition in diabetes. Copyright © 2017 Elsevier Inc. All rights reserved.

    Citation

    Jessica Weaver, David A Taylor-Fishwick. Relationship of NADPH Oxidase-1 expression to beta cell dysfunction induced by inflammatory cytokines. Biochemical and biophysical research communications. 2017 Apr 01;485(2):290-294

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    PMID: 28232183

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