The gut is believed to be the source of GLP-1 that augments insulin secretion in response to oral nutrients. In this issue of Cell Metabolism, Chambers et al. (2017) shift the paradigm by finding that GLP-1 produced within the islets of the pancreas, and not the gut, is responsible for the incretin effect in mice. Copyright © 2017 Elsevier Inc. All rights reserved.
Joel F Habener, Violeta Stanojevic. Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect. Cell metabolism. 2017 Apr 04;25(4):757-758
PMID: 28380367
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