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Antioxidant therapy is a promising treatment strategy for protecting DNA from the damage caused by reactive oxygen species (ROS). Here, we report new self-cyclizing antioxidant reagents that are selective for the hydroxyl radical. Our mechanistic investigation revealed that the reagents react with three equivalents of oxidant in a cascade reaction to form a bicyclic final product. Among the reagents synthesized, 1 c showed favorable properties in vitro and in cellular studies. Using As2 O3 , which triggers ROS production, we showed that 1 c prevents formation of the guanine oxidation product 2,2,4-triamino-2H-oxazol-5-one-2'-deoxyribonucleoside and lowers cellular levels of reactive oxygen. The described self-cyclizing antioxidants are efficient, flexible, and tunable reagents with the potential to limit toxic oxidative stress. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Safnas F AbdulSalam, Purujit N Gurjar, Haizhou Zhu, Jing Liu, Emma S Johnson, Ana Luisa Kadekaro, Julio Landero-Figueroa, Edward J Merino. Self-Cyclizing Antioxidants to Prevent DNA Damage Caused by Hydroxyl Radical. Chembiochem : a European journal of chemical biology. 2017 Oct 18;18(20):2007-2011

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PMID: 28810083

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