Although the cytochrome P450 CYP27B1 plays a critical role in vitamin D biology, the molecular mechanisms involved in regulation of CYP27B1 have remained undefined. A new study has identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basal activity and hormonal regulation of Cyp27b1 This work provides a novel mechanism indicating differential regulation of Cyp27b1 in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.
Sylvia Christakos. In search of regulatory circuits that control the biological activity of vitamin D. The Journal of biological chemistry. 2017 Oct 20;292(42):17559-17560
PMID: 29055009
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