Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Nucleotide repeat expansions in the C9orf72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Unconventional translation (RAN translation) of C9orf72 repeats generates dipeptide repeat proteins that can cause neurodegeneration. We performed a genetic screen for regulators of RAN translation and identified small ribosomal protein subunit 25 (RPS25), presenting a potential therapeutic target for C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia and other neurodegenerative diseases caused by nucleotide repeat expansions.

Citation

Shizuka B Yamada, Tania F Gendron, Teresa Niccoli, Naomi R Genuth, Rosslyn Grosely, Yingxiao Shi, Idoia Glaria, Nicholas J Kramer, Lisa Nakayama, Shirleen Fang, Tai J I Dinger, Annora Thoeng, Gabriel Rocha, Maria Barna, Joseph D Puglisi, Linda Partridge, Justin K Ichida, Adrian M Isaacs, Leonard Petrucelli, Aaron D Gitler. RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nature neuroscience. 2019 Sep;22(9):1383-1388

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 31358992

View Full Text