Eva Michaud, Carmelo Mastrandrea, Nicolas Rochereau, Stéphane Paul
Trends in immunology 2020 FebSecretory IgMs (SIgMs) were amongst the first identified immunoglobulins. However, their importance was not fully understood and recent advances have shown they play a key role in establishing and promoting commensal gut tolerance in mice and humans. The true interactions between SIgMs and the microbiota remain controversial and we aim to consolidate current knowledge in this review. Through comprehensive examination of SIgMs and their corresponding B cell secretors in several different pathological immunological contexts, we review the presumed role of these molecules in gut tolerance, inflammatory bowel diseases, and lung immunity. As SIgMs harbor a mostly tolerogenic function, we posit that their inclusion in further immunological research is paramount. Copyright © 2019 Elsevier Ltd. All rights reserved.
Eva Michaud, Carmelo Mastrandrea, Nicolas Rochereau, Stéphane Paul. Human Secretory IgM: An Elusive Player in Mucosal Immunity. Trends in immunology. 2020 Feb;41(2):141-156
PMID: 31928913
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