Correlation Engine 2.0
Clear Search sequence regions


  • americas (1)
  • flavivirus (1)
  • humans (1)
  • ns3 (3)
  • peptides (1)
  • polyprotein (1)
  • viral proteins (2)
  • Sizes of these terms reflect their relevance to your search.

    In recent years, the Zika virus has emerged from a neglected flavivirus to a health-threatening pathogen that causes epidemic outbreaks associated with neurological disorders and congenital malformations. In addition to vaccine development, the discovery of specific antiviral agents has been pursued intensely. The Zika virus protease NS2B-NS3 catalyses the processing of the viral precursor polyprotein as an essential step during viral replication. Since the epidemic Zika virus outbreak in the Americas, several inhibitors of this protease have been reported. Substrate-derived peptides revealed important structural information about the active site, whilst more drug-like small molecules have been discovered as allosteric inhibitors. Copyright © 2020 Elsevier Ltd. All rights reserved.

    Citation

    Saan Voss, Christoph Nitsche. Inhibitors of the Zika virus protease NS2B-NS3. Bioorganic & medicinal chemistry letters. 2020 Mar 01;30(5):126965

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 31980339

    View Full Text