We herein report the case of a young patient who presented with premature thromboembolic venous disease secondary to combined heterozygous G20210A prothrombin mutation, dual homozygosity for Factor V Leiden, and severe protein S deficiency. This association has never been reported to date and is likely to be exceptional, even in populations wherein these thrombophilia traits are more common. Long-term antithrombotic prophylaxis with rivaroxaban has proven successful in preventing clinical recurrence under prolonged treatment.
Evelien Krumb, Cédric Hermans. An exceptional case of severe combined inherited thrombophilia successfully treated with rivaroxaban. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2020 Jun;31(4):279-282
PMID: 32108680
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