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Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein. Recent evidence suggests a key role for lipidic molecules in the regulation of necroptosis. The purpose of this mini-review is to outline the regulation of necroptosis by sphingolipids and phospholipids.

Citation

Xuewei Zhang, Masaya Matsuda, Nobuo Yaegashi, Takeshi Nabe, Kazuyuki Kitatani. Regulation of Necroptosis by Phospholipids and Sphingolipids. Cells. 2020 Mar 05;9(3)

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PMID: 32151027

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