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    Aldosterone-producing zona glomerulosa (zG) cells of the adrenal gland arrange in distinct multi-cellular rosettes that provide a structural framework for adrenal cortex morphogenesis and plasticity. Whether this cyto-architecture also plays functional roles in signaling remains unexplored. To determine if structure informs function, we generated mice with zG-specific expression of GCaMP3 and imaged zG cells within their native rosette structure. Here we demonstrate that within the rosette, angiotensin II evokes periodic Cav3-dependent calcium events that form bursts that are stereotypic in form. Our data reveal a critical role for angiotensin II in regulating burst occurrence, and a multifunctional role for the rosette structure in activity-prolongation and coordination. Combined our data define the calcium burst as the fundamental unit of zG layer activity evoked by angiotensin II and highlight a novel role for the rosette as a facilitator of cell communication.

    Citation

    Nick A Guagliardo, Peter M Klein, Christina A Gancayco, Adam Lu, Sining Leng, Rany R Makarem, Chelsea Cho, Craig G Rusin, David T Breault, Paula Q Barrett, Mark P Beenhakker. Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes. Nature communications. 2020 Apr 03;11(1):1679

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    PMID: 32245948

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