Joyce Wanjiru Maingi, Shu Tang, Sirui Liu, Watson Ngenya, Endong Bao
Molecular biology reports 2020 MayHormones have become a useful therapeutic aspect of clinical endocrinology but how to use them to optimize the health benefits and avoid adverse effects is a major challenge. Estrogen is an indispensable hormone for proper biological functioning but is also implicated with the pathology of both the reproductive and non-reproductive tissues. Abnormal estrogen receptor signaling may increase the risk of development of a variety of diseases including colorectal cancer (CRC). Estrogen receptor beta (ERβ) is the predominant subtype in the colonic epithelium and confers the anti-tumor effect through various mechanisms. Many investigators have embarked on the search for the biological mechanisms by which estrogen and estrogen-like compounds may influence the pathogenesis of CRC. This review explores the recent findings on the therapeutic role of ERβ in the colonic epithelium as a prospective candidate for targeted endocrine therapy in CRC.
Joyce Wanjiru Maingi, Shu Tang, Sirui Liu, Watson Ngenya, Endong Bao. Targeting estrogen receptors in colorectal cancer. Molecular biology reports. 2020 May;47(5):4087-4091
PMID: 32246248
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