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    Lactate accumulation in tumors-a hallmark of the Warburg effect-has recently been shown to regulate cancer cell metabolism and survival through autocrine activation of GPR81. Now, Brown et al. (2020) demonstrate that lactate surprisingly also controls immune evasion through paracrine activation of GPR81 on stromal dendritic cells. Copyright © 2020 Elsevier Inc. All rights reserved.

    Citation

    Kathrine Lundø, Mette Trauelsen, Stine F Pedersen, Thue W Schwartz. Why Warburg Works: Lactate Controls Immune Evasion through GPR81. Cell metabolism. 2020 Apr 07;31(4):666-668

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    PMID: 32268113

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