Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Anthracyclines are ranked among the most effective chemotherapeutics against cancer. They are glycoside drugs comprising the amino sugar daunosamine linked to a hydroxy anthraquinone aglycone, and act by DNA intercalation, oxidative stress generation and topoisomerase II poisoning. Regardless of their therapeutic value, multidrug resistance and severe cardiotoxicity are important limitations of anthracycline treatment that have prompted the discovery of novel analogues. This review covers the most clinically relevant anthracyclines and their development over decades, since the first discovered natural prototypes to recent semisynthetic and synthetic derivatives. These include registered drugs, drug candidates undergoing clinical trials, and compounds under pre-clinical investigation. The impact of the structural modifications on antitumour activity, toxicity and resistance profile is addressed. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Maristela B Martins-Teixeira, Ivone Carvalho. Antitumour Anthracyclines: Progress and Perspectives. ChemMedChem. 2020 Jun 04;15(11):933-948

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 32314528

View Full Text