Julie Oniszczuk, Anissa Moktefi, Aude Mausoleo, Nicolas Pallet, Stephanie Malard-Castagnet, Slim Fourati, Khalil El Karoui, Dil Sahali, Thomas Stehlé, Anna Boueilh, Marie-Christine Verpont, Marie Matignon, David Buob, Philippe Grimbert, Vincent Audard
Transplantation 2021 Jan 01There is compelling evidence that renal complications in a native kidney are a major concern in patients infected with severe acute respiratory syndrome coronavirus 2, the causal agent of coronavirus disease 2019 (COVID-19). The spectrum of renal lesions observed on renal grafts in this context remains to be determined. We report the case of a renal transplant recipient with non-severe COVID-19, who subsequently developed nephrotic syndrome associated with acute renal injury. Renal biopsy demonstrated focal and segmental glomerulosclerosis lesions classified as not otherwise specified histological variant. Genotyping for 2 risk alleles of the apolipoprotein L1 gene demonstrated that the donor was homozygous for the G2/G2 genotype. In renal transplant patients receiving kidneys from donors with high-risk apolipoprotein L1 variants, COVID-19 may promote acute glomerular injury in the form of focal and segmental glomerulosclerosis. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Julie Oniszczuk, Anissa Moktefi, Aude Mausoleo, Nicolas Pallet, Stephanie Malard-Castagnet, Slim Fourati, Khalil El Karoui, Dil Sahali, Thomas Stehlé, Anna Boueilh, Marie-Christine Verpont, Marie Matignon, David Buob, Philippe Grimbert, Vincent Audard. De Novo Focal and Segmental Glomerulosclerosis After COVID-19 in a Patient With a Transplanted Kidney From a Donor With a High-risk APOL1 Variant. Transplantation. 2021 Jan 01;105(1):206-211
PMID: 32852403
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